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- Title
Matching of Host Genotype and Serotypes of Coxsackie B Virus in the Development of Juvenile Diabetes.
- Authors
Fohlman, J.; Böhme, J.; Rask, L.; Frisk, G.; Diderholm, H.; Friman, G.; Tuvemo, T.
- Abstract
Thirty-six consecutive paediatric patients (0-16 years old) with recently contracted juvenile diabetes (IDDM) during 1982-84 were included in the study. Sera were assayed for recent or current Coxsackie B virus (CBV) infection using a specific and sensitive IgM RIA, Eighteen patients (50%) had IgM against CBV 1-5, The patients were also assayed for restriction fragment length polymorphism (RFLP) patterns with DNA probes coding for HLA-DR and DQ beta chains. The CBV-positive patients (n=18) had either RFLP patterns associated with HLA-DR 3 or 4 or HLA-DQ patterns III or IV beta. Two of the CBV negative patients had neither HLA-DR 3 nor DR 4 and four of them had neither DQ patterns III nor IV, Eleven out of 18 CBV-positive patients had HLA-DQ III and DR 3 (61%) versus 5 out of 18 (28%) of the CBV-negative patients. All 11 patients with serology positive for CBV 2,3, and 5 had HLA-DR 4 and DQ IV patterns. This was significantly (P<0.01) different from all five CBV 4-positive patients, who in contrast all had HLA-DR 3 or HLA-DQ III patterns, CBV 1-positive patients (n=2) all had HLA-DR 3, 4, and HLA-DQ III, IV patterns. Thus CBV 4 seems to be significantly associated with a different host genetic constitution from at any rate CBV 2,3, and 5, and possibly CBV 1.
- Subjects
DIABETES in children; COXSACKIEVIRUSES; RESTRICTION fragment length polymorphisms; DNA probes; SEROLOGY; PATIENTS
- Publication
Scandinavian Journal of Immunology, 1987, Vol 26, Issue 2, p105
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1987.tb02242.x