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- Title
Relationships between HLA-DR-expressing Cells and T Lymphocytes of Different Subsets in Rheumatoid Synovial Tissue.
- Authors
Klareskog, L.; Forsum, U.; Wigren, A.; Wigzell, H.
- Abstract
An immunohistochemical double staining technique was used lo study the relationships between HLA-DR-expressing, mostly macrophage-like cells, and different populations of T lymphocytes in frozen sections of synovial tissue from patients with inflammatory joint disease, particularly rheumatoid arthritis. Substantial T-lymphocyte inflammatory as measured by Leu 1 antibody binding was found, especially adjacent to HLA-DR-expressing cells near the synovial cavity and around small vessels. Most of the T cells reacted with Leu 3a ('helper/inducer'-cell-specific) antibodies, whereas relatively few cells were Leu 2a ('cytotoxic/suppressor' T-cell-specific)-positive.
- Subjects
IMMUNOHISTOCHEMISTRY; MACROPHAGES; CONNECTIVE tissue cells; T cells; LYMPHOCYTES; IMMUNOGLOBULINS
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 5, p501
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00676.x