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- Title
Hydrocortisone Abrogates Proliferation of T Cells in Autologous Mixed Lymphocyte Reaction by Rendering the Interleukin-2 Producer T Cells Unresponsive to Interleukin-1 and Unable to Synthesize the T-Cell Growth Factor.
- Authors
Palscios, R.; Sugawara, I.
- Abstract
Hydrocortisone (HC-A) inhibited the proliferative response in the autologous mixed lymphocyte reaction (AMLR). The inhibitory activity became apparent 48 h after initiation of the cultures and was maintained throughout the culture period. T cells from cultures treated with HC-A showed a proliferative response to interleukin-2 (IL-2) of a similar degree as T cells from cultures not exposed to this drug. Hydrocortisone abrogated the production of IL-2 in AMLR. The addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A-treated cultures significantly enhanced the synthesis of IL-2. Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR. These results indicate that HC-A inhibits proliferation of T cells in AMLR by causing the IL-2 producer T cells to become unresponsive to IL-1 and unable to synthesize IL-2. This drug does not, however, interfere with the process by which resting T cells acquire responsiveness to IL-2.
- Subjects
HYDROCORTISONE; LYMPHOCYTES; T cells; CELL culture; INTERLEUKIN-2; GLUCOCORTICOIDS
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 1, p25
- ISSN
0300-9475
- Publication type
Article