We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Resveratrol attenuates radiation-induced salivary gland dysfunction in mice.
- Authors
Xu, Liping; Yang, Xi; Cai, Jing; Ma, Jianxin; Cheng, Hongyan; Zhao, Kuiling; Yang, Liping; Cao, Yuandong; Qin, Qin; Zhang, Chi; Zhang, Qu; Sun, Xinchen
- Abstract
Objectives/Hypothesis In our study we investigated the radioprotective effect of resveratrol (RES) in a murine model of radiation-induced salivary gland dysfunction. Study Design Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent (group I), RES treated (group II; 20mg/kg/d), 15 Gy irradiation with solvent treatment (group III), and 15 Gy irradiation with RES treatment (group IV; 15 Gy and 20 mg/kg/d RES). RES (group II and IV) was administered intraperitoneally 3 days prior to irradiation through the conclusion of the experiment. Methods Saliva and submandibular gland tissues were obtained for biochemical, morphological, immunohistochemical, and Western blot analyses at 8 hours, 24 hours, and 30 days after localized irradiation. Results Radiation caused a reduction of saliva secretion, salivary amylase activity, superoxide dismutase, and an elevation of malondialdehyde. Administration of RES reversed the reduction of saliva secretion induced by irradiation and restored salivary amylase and superoxide dismutase activity. In addition, RES could inhibit increases in transforming growth factor-β1 expression induced by radiation. Conclusions RES can protect salivary glands against the negative effects of irradiation and has great potential as a treatment for successful radiotherapy in clinical practice. Level of Evidence N/A. Laryngoscope, 123:E23-E29, 2013
- Subjects
SALIVARY gland diseases; RESVERATROL; RADIATION exposure; RADIATION-protective agents; LABORATORY mice; DRUG administration; ANTIOXIDANTS
- Publication
Laryngoscope, 2013, Vol 123, Issue 11, pE23
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.24276