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- Title
Clinical significance of preoperative squamous cell carcinoma antigen in oral-cavity squamous cell carcinoma.
- Authors
Lin, Wei-Hung; Chen, I-How; Wei, Fu-Chan; Huang, Jung-Ju; Kang, Chung-Jan; Hsieh, Ling-Ling; Wang, Hung-Ming; Huang, Shiang-Fu
- Abstract
Objectives/Hypothesis: Previous studies have demonstrated a relationship between elevated serum squamous cell carcinoma (SCC) antigen (SCC-Ag) levels and shorter survival in cancer patients. Few studies, however, have investigated the role of serum SCC-Ag levels in oral SCC (OSCC). This study was conducted to analyze the relationship between preoperative SCCAg levels, clinicopathologic factors, and prognosis in OSCC patients. Stud Design: Retrospective case-control study. Methods: Seventy-nine OSCC patients from Chang Gung Memorial Hospital were retrospectively recruited between April 2008 and March 2010. Serum SCC-Ag levels were measured preoperatively. Results: An SCC-Ag level of ≥2.0 ng/mL was significantly associated with the pathologic tumor status (P < .001), pathologic nodal status (P = .037), lymph node extracapsular spread (P = .016), and tumor depth (>10 mm vs. ≥10 mm, P < .001). It was not significantly associated with histologic differentiation (P = 1.000). A univariate analysis revealed that positivity for SCC-Ag was associated with disease-free survival (DFS) (P = .034) and overall survival (OS) (P < .001). In SCC-Agpositive patients, the distant metastatic rate was higher than in the SCC-Ag-negative patients (P = .053). Conclusions: This study demonstrated that preoperative SCC-Ag is a good marker of pathologic lymph node metastasis, an advanced tumor stage, and a higher rate of distant metastasis. The preoperative SCC-Ag level is a potential prognostic indicator in DFS and OS, but studies with a longer follow-up period are needed to confirm these results.
- Subjects
CELLS; ANTIGENS; CANCER patients; CASE-control method; LYMPH nodes; HISTOLOGY; CANCER
- Publication
Laryngoscope, 2011, Vol 121, Issue 5, p971
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.21721