We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of the Level and Duration of SARS-Cov-2 Neutralizing Antibodies in COVID-19 Convalescent Healthcare Workers.
- Authors
Mousa, Zeena S.; Abdulamir, Ahmed S.
- Abstract
Background: The neutralizing antibodies (nAbs) are the main factor for the protective immunity against viruses. Objective: To evaluate the level and duration of anti-receptor-binding domain (RBD) nAbs for 8 months in convalescent Coronavirus disease-2019 (COVID-19) patients with a history of mild-moderate and severe disease. Methods: Up to 160 sera from COVID-19 convalescent hospital healthcare workers (HCWs) with a history of mild-moderate and severe disease at 1-, 3-, 5-, and 8-month post-recovery using in-house developed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-RBD neutralizing competitive enzyme-linked immunosorbent assay (ELISA). Results: SARS-CoV-2 nAbs persisted till 8 months post-recovery in most convalescent patients, the level of nAbs in severe disease group was higher than in mild-moderate disease group; moreover, anti-RBD nAbs mean concentrations in COVID-19 convalescent HCWs tend to increase over time after infection. Similarly, frequency of samples with positive anti-RBD nAbs also tends to increase over time post-recovery. Conclusion: The protective immunity to SARS-CoV-2 in HCWs was found to last for a long time exceeding 8 months after recovery. The increase in the mean level of nAbs over time in COVID-19 convalescent HCWs might be attributed to the frequent asymptomatic re-exposures in HCWs.
- Subjects
SARS-CoV-2; MEDICAL personnel; COVID-19
- Publication
Iraqi Journal of Medical Sciences, 2023, Vol 21, Issue 1, p30
- ISSN
1681-6579
- Publication type
Article
- DOI
10.22578/IJMS.21.1.4