We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Non-HDL cholesterol and long-term follow-up outcomes in patients with metabolic syndrome.
- Authors
Vazirian, Fatemeh; Darroudi, Susan; Rahimi, Hamid Reza; Latifi, MohamadReza; Shakeri, Behrouz; Abolbashari, Samaneh; Mohammadpour, Amir Hooshang; Esmaily, Habibollah; Mouhebati, Mohsen; Samadi, Sara; Mobarhan, Majid Ghayour
- Abstract
Background: Non-high-density lipoprotein-cholesterol (non-HDL-C) has been identified as a potential biomarker for metabolic syndrome (MetS). However, its predictive capability for MetS varies among different ethnic groups, necessitating further investigation. This study aimed to assess the role of non-HDL-C in the early diagnosis of MetS in the Iranian population through a longitudinal study with a 10-year follow-up period. Methods: Our study enrolled 4684 individuals from the MASHAD (Mashhad Stroke and Heart Atherosclerotic Disorder) cohort who were followed for 10 years to examine the association between non-HDL-C and the incidence of MetS. Additionally, the contribution of individual MetS components to the overall burden was evaluated. Results: A total of 1599 subjects developed MetS, while 3085 did not. Non-HDL-C levels ≥ 130 were associated with a 42% higher risk of developing MetS (relative risk (RR), 1.42; 95% confidence interval (CI), 1.25–1.62). Regarding MetS components, elevated waist circumference (WC) showed the strongest association with MetS incidence (RR, 2.32; 95% CI, 1.45–2.9), whereas triglyceride (TG) levels ≥ 150 mg/dL demonstrated the weakest association (RR, 1.23; 95% CI, 1.04–1.46). Additionally, higher HDL-C levels were reported to be 20% protective against the risk of MetS (RR, 0.8; 95% CI, 0.73–0.86). Moreover, fasting blood glucose (FBG) levels ≥ 100 mg/dL were not significantly linked to MetS burden, while systolic blood pressure (BP) levels ≥ 130 mmHg or diastolic BP levels ≥ 85 mmHg increased the risk of MetS incidence (RR, 1.25; 95% CI: 1.11–1.41). Conclusions: Elevated non-HDL-C and increased WC serve as significant predictors of MetS in Iranians. Strategies targeting non-HDL-C levels and weight loss should be emphasized to mitigate the risk of MetS development.
- Subjects
METABOLIC syndrome; SYSTOLIC blood pressure; HIGH density lipoproteins; WAIST circumference; IRANIANS; TREATMENT effectiveness
- Publication
Lipids in Health & Disease, 2023, Vol 22, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-023-01923-y