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- Title
Drug delivery strategy in hepatocellular carcinoma therapy.
- Authors
Yang, Sisi; Cai, Chengwei; Wang, Huanqiu; Ma, Xueqing; Shao, Anwen; Sheng, Jifang; Yu, Chengbo
- Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with high rates of recurrence and death. Surgical resection and ablation therapy have limited efficacy for patients with advanced HCC and poor liver function, so pharmacotherapy is the first-line option for those patients. Traditional antitumor drugs have the disadvantages of poor biological distribution and pharmacokinetics, poor target selectivity, high resistance, and high toxicity to nontargeted tissues. Recently, the development of nanotechnology has significantly improved drug delivery to tumor sites by changing the physical and biological characteristics of drugs and nanocarriers to improve their pharmacokinetics and biological distribution and to selectively accumulate cytotoxic agents at tumor sites. Here, we systematically review the tumor microenvironment of HCC and the recent application of nanotechnology in HCC. 4yR9ZE2akgJiF2XmjN2GAm Video Abstract.
- Subjects
HEPATOCELLULAR carcinoma; ABLATION techniques; ANTINEOPLASTIC agents; TUMOR microenvironment; SURGICAL flaps; DRUGS; DRUG delivery systems
- Publication
Cell Communication & Signaling, 2022, Vol 20, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-021-00796-x