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- Title
Diversity of greek meningococcal serogroup B isolates and estimated coverage of the 4CMenB meningococcal vaccine.
- Authors
Tzanakaki, Georgina; Hong, Eva; Kesanopoulos, Konstatinos; Xirogianni, Athanasia; Bambini, Stefania; Orlandi, Luca; Comanducci, Maurizio; Muzzi, Alessandro; Taha, Muhamed-Kheir
- Abstract
Background Serogroup B meningococcal (MenB) isolates currently account for approximately 90% of invasive meningococcal disease (IMD) in Greece with ST-162 clonal complex predominating. The potential of a multicomponent meningococcal B vaccine (4CMenB) recently licensed in Europe was investigated in order to find whether the aforementioned vaccine will cover the MenB strains circulating in Greece. A panel of 148 serogroup B invasive meningococcal strains was characterized by multilocus sequence typing (MLST) and PorA subtyping. Vaccine components were typed by sequencing for factor H-binding protein (fHbp), Neisserial Heparin Binding Antigen (NHBA) and Neisseria adhesin A (NadA). Their expression was explored by Meningococcal Antigen Typing System (MATS). Results Global strain coverage predicted by MATS was 89.2% (95% CI 63.5%-98.6%) with 44.6%, 38.5% and 6.1% of strains covered by one, two and three vaccine antigens respectively. NHBA was the antigen responsible for the highest coverage (78.4%), followed by fHbp (52.7%), PorA (8.1%) and NadA (0.7%). The coverage of the major genotypes did not differ significantly. The most prevalent MLST genotype was the ST-162 clonal complex , accounting for 44.6% of the strains in the panel and with a predicted coverage of 86.4%, mainly due to NHBA and fHbp. Conclusions 4CMenB has the potential to protect against a significant proportion of Greek invasive MenB strains.
- Subjects
GREECE; MENINGOCOCCAL vaccines; MENINGITIS treatment; LOCUS (Genetics); NUCLEOTIDE sequence; CARRIER proteins; ANTIGENS
- Publication
BMC Microbiology, 2014, Vol 14, Issue 1, p1
- ISSN
1471-2180
- Publication type
Article
- DOI
10.1186/1471-2180-14-111