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- Title
DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems.
- Authors
Memiševic, Vesna; Kumar, Kamal; Zavaljevski, Nela; DeShazer, David; Wallqvist, Anders; Reifman, Jaques
- Abstract
Background: and are the causative agents of glanders and melioidosis, Burkholderia mallei B. pseudomallei respectively, diseases with high morbidity and mortality rates. and are closely related B. mallei B. pseudomallei genetically; evolved from an ancestral strain of by genome reduction and adaptation to an B. mallei B. pseudomallei obligate intracellular lifestyle. Although these two bacteria cause different diseases, they share multiple virulence factors, including bacterial secretion systems, which represent key components of bacterial pathogenicity. Despite recent progress, the secretion system proteins for and their pathogenic mechanisms of B. mallei B. pseudomallei, action, and host factors are not well characterized. Results: We previously developed a manually curated database, DBSecSys, of bacterial secretion system proteins for B. mallei. Here, we report an expansion of the database with corresponding information about . B. pseudomallei DBSecSys 2.0 contains comprehensive literature-based and computationally derived information about B. mallei ATCC 23344 and literature-based and computationally derived information about K96243. The B. pseudomallei database contains updated information for 163 proteins from the previous database and 61 additional B. mallei B. mallei proteins, and new information for 281 proteins associated with 5 secretion systems, their B. pseudomallei 1,633 human- and murine-interacting targets, and 2,400 host- interactions and 2,286 host- B. mallei B. pseudomallei interactions. The database also includes information about 13 pathogenic mechanisms of action for and B. mallei B. pseudomallei secretion system proteins inferred from the available literature or computationally. Additionally, DBSecSys 2.0 provides details about 82 virulence attenuation experiments for 52 secretion system proteins B. mallei and 98 virulence attenuation experiments for 61 secretion system proteins. We updated the Web B. pseudomallei interface and data access layer to speed-up users' search of detailed information for orthologous proteins related to secretion systems of the two pathogens. Conclusions: The updates of DBSecSys 2.0 provide unique capabilities to access comprehensive information about secretion systems of and . They enable studies and comparisons of corresponding proteins B. mallei B. pseudomallei of these two closely related pathogens and their host-interacting partners. The database is available at http://dbsecsys.bhsai.org.
- Subjects
MELIOIDOSIS; GLANDERS; INTRACELLULAR pathogens; BACTERIAL secretions; MICROBIAL virulence
- Publication
BMC Bioinformatics, 2016, Vol 17, p1
- ISSN
1471-2105
- Publication type
Article
- DOI
10.1186/s12859-016-1242-z