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- Title
Studying both sexes: a guiding principle for biomedicine.
- Authors
Clayton, Janine Austin
- Abstract
In May 2014, the U.S. National Institutes of Health (NIH) announced that it will ensure that investigators account for sex as a biological variable (SABV) in NIHfunded preclinical research as part of the agency's rigor and transparency initiative. Herein, I describe in more detail the rationale behind the SABV policy component and provide additional detail about policy goals. In short, studying both sexes is a guiding principle in biomedical research that will expand knowledge toward turning discovery into health.NIH expects that considering SABV in preclinical research will help to build a knowledge base that better informs the design of clinical research and trials in humans. Integrating the practice of studying both sexes in preclinical research will, over time, expand our currently incomplete knowledge base that plays a critical role in informing the development of sexand gender-appropriatemedical care forwomenandmen.
- Subjects
NATIONAL Institutes of Health (U.S.); CLINICAL trials; HEALTH policy; MEDICAL research; MEDICAL care
- Publication
FASEB Journal, 2016, Vol 30, Issue 2, p519
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.15-279554