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- Title
Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial.
- Authors
Luiza Soares Rodrigues, Ana; Guitton Renaud Baptista de Oliveira, Beatriz; Omena Futuro, Débora; Regina Secoli, Silvia
- Abstract
Objective: to assess the effectiveness of 2% papain gel compared to 2% carboxymethyl cellulose in the treatment of chronic venous ulcer patients. Method: randomized controlled clinical trial with 12-week follow-up. The sample consisted of 18 volunteers and 28 venous ulcers. In the trial group, 2% papain gel was used and, in the control group, 2% carboxymethyl cellulose gel. Results: the trial group showed a significant reduction in the lesion area, especially between the fifth and twelfth week of treatment, with two healed ulcers and a considerable increase in the amount of epithelial tissue in the wound bed. Conclusion: 2% papain gel demonstrated greater effectiveness in the reduction of the lesion area, but was similar to 2% carboxymethyl cellulose gel regarding the reduction in the amount of exudate and devitalized tissue. Multicenter research is suggested to evidence the effectiveness of 2% papain gel in the healing of venous ulcers. UTN number: U1111-1157-2998
- Subjects
ULCER treatment; LEG ulcers; CELLULOSE; CHI-squared test; CLINICAL medicine; DIABETES; PHARMACEUTICAL gels; GRANULATION tissue; EVALUATION of medical care; PROBABILITY theory; PULMONARY hypertension; STATISTICS; VENOUS insufficiency; WOUND healing; PLANT extracts; DATA analysis; TREATMENT effectiveness; MANN Whitney U Test; PHARMACODYNAMICS
- Publication
Revista Latino-Americana de Enfermagem (RLAE), 2015, Vol 23, Issue 3, p458
- ISSN
1518-8345
- Publication type
Article
- DOI
10.1590/0104-1169.0381.2576