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- Title
Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.
- Authors
Wu, Rongzhen; Chen, Hongyu; Chang, Ninghui; Xu, Yuzhi; Jiao, Jiao; Zhang, Hailong
- Abstract
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014–present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most‐studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.
- Subjects
ALZHEIMER'S disease; AIDS treatment; DRUGS; ANTINEOPLASTIC agents
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 6, p1166
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201903128