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- Title
A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid.
- Authors
Akihiro Tai; Mei Aburada; Hideyuki Ito
- Abstract
The article presents study on synthesis and biological evaluation of 3-O-ethylascorbic acid. It mentions the reaction of Sodium L-ascorbate with ethyl bromide in dimethyl sulfoxide (DMSO) to give 3-O-ethylascorbic acid. It adds the effects of the ethylation agent and reaction temperature on 3-O-ethylascorbic acid formation and no need to add sodium hydrogen carbonate as a base to the reaction system after replacing ascorbic acid with sodium ascorbate as a starting material.
- Subjects
VITAMIN C; DIMETHYL sulfoxide; ETHYL bromide; ETHYLATION; CHEMICAL reactions
- Publication
Bioscience, Biotechnology & Biochemistry, 2014, Vol 78, Issue 12, p1984
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2014.946396