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- Title
Pyridoxine 5′-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.
- Authors
Kwak, Sung-Eun; Kim, Ji-Eun; Kim, Dae-Won; Kwon, Oh-Shin; Choi, Soo-Young; Kang, Tae-Cheon
- Abstract
In this study, we investigated whether the expression of pyridoxal kinase (PLK) and pyridoxine-5′-phosphate oxidase (PNPO) are altered following long-term potentiation (LTP) induction, and whether Tat-PLK and Tat-PNPO transductions affect LTP induction and paired-pulse responses in the rat dentate gyrus (DG). PNPO immunoreactivity was markedly increased in dentate granule cells after the induction of LTP, but that of PLK was not. Tat-PNPO (20 and 200 μg/kg), but not Tat-PLK or vitamin B6 precursors, treatments, increased the efficiency of high frequency stimulus-induced potentiation of populations spike amplitude when compared with saline-, or Tat-protein-treated animals. These changes correlated with the alterations in PNPO activity and its immunoreactivity. In addition, Tat-PNPO transduction increased paired-pulse facilitation but had no effect on the fast and late paired-pulse inhibitions. These findings suggest that PNPO may play a role in activity-dependent regulation of PLP level in the brain, which is involved in LTP induction and paired-pulse facilitation but not in enhancement of GABAergic inhibition. © 2008 Wiley-Liss, Inc.
- Publication
Hippocampus, 2009, Vol 19, Issue 1, p45
- ISSN
1050-9631
- Publication type
Article
- DOI
10.1002/hipo.20477