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- Title
Cerebrovascular pathology in cerebral amyloid angiopathy presenting as intracerebral haemorrhage.
- Authors
Poyuran, Rajalakshmi; Mahadevan, Anita; Arimappamagan, Arivazhagan; Nandeesh, B. N.; Nagappa, Madhu; Saini, Jitender; Narasinga Rao, K. V. L.; Chickabasaviah, Yasha T.
- Abstract
Cerebral amyloid angiopathy (CAA) is the second most common cause of non-traumatic intracerebral haemorrhage (ICH) accounting for 12-15% of lobar haemorrhages in the elderly. Definitive diagnosis of CAA requires histological evaluation. We aimed to evaluate the spectrum of cerebrovascular changes in CAA-related ICH. Between 2011 and 2015, biopsy-confirmed cases of CAA were retrieved and clinical, radiological and pathological features were reviewed. The spectrum of vascular alterations was evaluated and amyloid deposition was graded in accordance with the Greenberg and Vonsattel scale. Seven cases of sporadic CAA [5 males and 2 females] were diagnosed, none of whom were suspected to have CAA pre-operatively. Six presented with large intracerebral haematoma (ICH) requiring neurosurgical intervention (age range: 56-70 years) and one had episodic headache and multiple microhaemorrhages requiring a diagnostic brain biopsy (45 years). In the presence of large ICH, vascular amyloid deposits were of moderate to severe grade (grade 4 in 4, grades 2 and 3 in 1 case each) with predominant involvement of medium (200-500 μm) to large (> 500 μm) leptomeningeal vessels. Fibrinoid necrosis was noted in four. Two were hypertensive and on antiplatelet agents. β-Amyloid plaques were detected in two, one of whom had symptomatic dementia. MRI performed in 3 of 6 cases with ICH did not reveal any microhaemorrhages. Amyloid deposits in small (50-200 μm) to medium (200-500 μm) calibre intracortical vessels produced parenchymal microhemorrhages. Histopathological examination of ICH is essential for diagnosing CAA. The vascular calibre rather than grade of amyloid deposits dictates size of the bleed. Presence of co-morbidities such as antiplatelet agents may predispose to haemorrhage.
- Subjects
CEREBRAL amyloid angiopathy; MAGNETIC resonance imaging; PLATELET aggregation inhibitors; BIOPSY; AUTOPSY; CEREBRAL hemorrhage; CEREBROVASCULAR disease; NEUROSURGERY
- Publication
Virchows Archiv: European Journal of Pathology, 2019, Vol 474, Issue 2, p235
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-018-2505-z