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- Title
Influence of maternal genetic and lifestyle factors on bone mineral density in adolescent daughters: a cohort study in 387 Japanese daughter-mother pairs.
- Authors
Tatsuhiko Kuroda; Yoshiko Onoe; Yuko Miyabara; Remi Yoshikata; Seiya Orito; Ken Ishitani; Hiroya Okano; Hiroaki Ohta
- Abstract
Abstract We conducted a cross-sectional study in a cohort of Japanese adolescent schoolgirls (12–18 years of age) and their mothers (387 pairs). Age, lumbar bone mineral density (BMD), birth and menarche-related status, height, body weight and lifestyles were surveyed in the participants. The values of BMD, height and body weight were converted to standard deviation (SD) by age. There were 49 (12.7%) pre-menarche and 338 (87.3%) post-menarche daughters. BMD-SD, height-SD, vitamin D intake and vitamin K intake were significantly correlated between the pre-menarche daughters and mothers (P P R 2 = 0.069, P = 0.033) and their own height-SD (R 2 = 0.199, P = 0.001) (model R 2 = 0.340), independently. BMD-SD in the post-menarche daughters was affected by BMD-SD in mothers (R 2 = 0.073, P R 2 = 0.020, P = 0.001), height-SD (R 2 = 0.022, P R 2 = 0.081, P R 2 = 0.015, P = 0.045) (model R 2 = 0.372), independently. The results suggest that BMD is strongly correlated between daughters and mothers and that a greater age at menarche leads to lower peak bone mass. It was also suggested that maintaining high-intensity physical activity and adequate body weight is important in achieving maximum BMD as factors amenable to intervention in post-menarche daughters.
- Subjects
JAPAN; BONE density; LIFESTYLES; TEENAGE girls' health; COHORT analysis; MOTHER-daughter relationship; CROSS-sectional method
- Publication
Journal of Bone & Mineral Metabolism, 2009, Vol 27, Issue 3, p379
- ISSN
0914-8779
- Publication type
Article
- DOI
10.1007/s00774-009-0045-y