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- Title
Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk.
- Authors
Nian, Zekai; Mao, Yicheng; Xu, Zexia; Deng, Ming; Xu, Yixi; Xu, Hanlu; Chen, Ruoyao; Xu, Yiliu; Huang, Nan; Mao, Feiyang; Xu, Chenyu; Wang, Yulin; Niu, Mengyuan; Chen, Aqiong; Xue, Xiangyang; Zhang, Huidi; Guo, Gangqiang
- Abstract
Background: Studies have highlighted a possible crosstalk between the pathogeneses of COVID-19 and systemic lupus erythematosus (SLE); however, the interactive mechanisms remain unclear. We aimed to elucidate the impact of COVID-19 on SLE using clinical information and the underlying mechanisms of both diseases. Methods: RNA-seq datasets were used to identify shared hub gene signatures between COVID-19 and SLE, while genome-wide association study datasets were used to delineate the interaction mechanisms of the key signaling pathways. Finally, single-cell RNA-seq datasets were used to determine the primary target cells expressing the shared hub genes and key signaling pathways. Results: COVID-19 may affect patients with SLE through hematologic involvement and exacerbated inflammatory responses. We identified 14 shared hub genes between COVID-19 and SLE that were significantly associated with interferon (IFN)-I/II. We also screened and obtained four core transcription factors related to these hub genes, confirming the regulatory role of the IFN-I/II-mediated Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway on these hub genes. Further, SLE and COVID-19 can interact via IFN-I/II and IFN-I/II receptors, promoting the levels of monokines, including interleukin (IL)-6/10, tumor necrosis factor-α, and IFN-γ, and elevating the incidence rate and risk of cytokine release syndrome. Therefore, in SLE and COVID-19, both hub genes and core TFs are enriched within monocytes/macrophages. Conclusions: The interaction between SLE and COVID-19 promotes the activation of the IFN-I/II-triggered JAK-STAT signaling pathway in monocytes/macrophages. These findings provide a new direction and rationale for diagnosing and treating patients with SLE–COVID-19 comorbidity.
- Subjects
JAK-STAT pathway; SYSTEMIC lupus erythematosus; CYTOKINE release syndrome; MULTIOMICS; COVID-19; GENOME-wide association studies
- Publication
Molecular Medicine, 2024, Vol 30, Issue 1, p1
- ISSN
1076-1551
- Publication type
Article
- DOI
10.1186/s10020-024-00851-6