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- Title
Mutational Profile and New IASLC/ATS/ERS Classification Provide Additional Prognostic Information about Lung Adenocarcinoma: A Study of 125 Patients from Brazil.
- Authors
de Melo, Andreia Cristina; Karen de Sá, Vanessa; Sternberg, Cinthya; Olivieri, Eloisa Ribeiro; Werneck da Cunha, Isabela; Fabro, Alexandre Todorovic; Carraro, Dirce Maria; de Barros e Silva, Milton José; Pimenta Inada, Haynna Kimie; de Mello, Evandro Sobrosa; Soares, Fernando Augusto; Takagaki, Tereza; Ferreira, Carlos Gil; Capelozzi, Vera Luiza
- Abstract
Aim: To show additional prognostic information about the mutational profile and new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification of adenocarcinoma (ADC) in patients without epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor treatments. Methods: In human lung ADC patients (n = 125), including 24 lepidic, 67 acinar, 23 papillary, and 11 solid predominant subtypes, EGFR and KRAS were sequenced, and anaplastic lymphoma kinase (ALK) rearrangements were screened using fluorescence in situ hybridization (FISH). Results:EGFR was mutated in 21.6% of patients with 19.57% showing a mean expression. The most frequent EGFR mutation was a deletion in exon 19, followed by an L858R amino acid substitution in exon 21. KRAS was mutated in 26.4% of patients with 50% displaying mean expression. ALK rearrangement was detected in 6 patients (4.8%). Predominant acinar ADC was strongly associated with EGFR and KRAS mutation. Clinical stage, lymph node metastases, and EGFR mutation in exon 18 showed a significant difference in disease-free and overall survival, but only a trend significance for EGFR and KRAS mutations. Multivariate analysis revealed that men aged >71 years, with a history of smoking (<72 packs/year), clinical stage I/II, and acinar histologic subtype presented better survival than women aged ≤71 years, with a history of smoking (>72 packs/year), and having a predominant solid ADC and EGFR mutation in exon 18. Conclusions: These results indicate that the mutational profile and new IASLC/ATS/ERS classification provide additional prognostic information about lung ADC. © 2015 S. Karger AG, Basel
- Subjects
BRAZIL; ADENOCARCINOMA; ACADEMIC medical centers; STATISTICAL correlation; FISHER exact test; LUNG tumors; MULTIVARIATE analysis; GENETIC mutation; POLYMERASE chain reaction; RESEARCH funding; FLUORESCENCE in situ hybridization; PROPORTIONAL hazards models; RETROSPECTIVE studies; DATA analysis software; GENE expression profiling; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; PROGNOSIS
- Publication
Oncology, 2015, Vol 89, Issue 3, p175
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000376552