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- Title
Monozygotic Dichorionic Twins Heterokaryotypic for Duplication Chromosome 2q13-q23.3.
- Authors
Leung, W. C.; Choi, H.; Lau, W. L.; Ng, L. K.; Lau, E. T.; Lo, F. M.; Choy, K. W.; Lau, T. K.; Tang, M. H. Y.; Chin, R.
- Abstract
We present an evaluation of the diagnosis, management and outcome of a pair of heterokaryotypic monozygotic dichorionic twins. The heterokaryotype was an incidental finding from an amniocentesis performed for prenatal diagnosis of β-thalassaemia major in a pair of dichorionic twins. Monozygocity was revealed by QF-PCR showing identical short tandem repeat markers on chromosomes 21, 18, 13, X and Y. The twins were heterokaryotypic for duplication chromosome 2q13-q23.3, as shown by array comparative genomic hybridization. Selective foeticide was performed. This case demonstrates that heterokaryotypic monozygotic dichorionic twins are a genetic possibility that does occur. Copyright © 2009 S. Karger AG, Basel
- Subjects
CHROMOSOMES; TWINS; AMNIOCENTESIS; PRENATAL diagnosis; ABORTION; AMNIOTIC liquid
- Publication
Fetal Diagnosis & Therapy, 2009, Vol 25, Issue 4, p397
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000236153