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- Title
Influence of Temporary Abdominal Wall Repair on the Intestinal Integrity: An Experimental Study in the Rat.
- Authors
Overhaus, M.; Schaefer, N.; Hirner, A.; Kalff, J. C.; Tolba, R. H.
- Abstract
Background and Aims: The aim of this study was to analyze intestinal integrity after temporary abdominal wall repair with absorbable mesh. Methods: Rats underwent abdominal wall repair with absorbable mesh or sham operation. Myeloperoxidase-positive cells in the intestinal muscularis were histochemically quantified. Intestinal transit was visualized 48 h after surgery. Local and systemic inflammatory response was measured with TNF-α and IL-6 ELISA as well as malondialdehyde (MDA) expression in serum and peritoneal fluid. Results: Neutrophil count of the intestinal muscularis revealed that infiltration in the mesh-implanted and in the mesh-free animals 48 h postoperatively was similar. Gastrointestinal transit was similarly unaffected 48 h after surgery, with or without mesh implantation. TNF-α, IL-6 and MDA concentration in serum and peritoneal fluid showed no significant differences between the two groups. Conclusion: Intestinal contractility and local and systemic inflammatory response remained unaffected. Therefore, absorbable mesh augmentation is a safe and reliable method for temporary repair of the abdominal wall without affecting the intestinal integrity. Copyright © 2008 S. Karger AG, Basel
- Subjects
ABDOMINAL wall; SURGERY; PERITONEUM; SERUM; ABDOMINAL muscles
- Publication
European Surgical Research, 2008, Vol 40, Issue 1, p55
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000109342