We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Trypanocidal activity and acute toxicity assessment of triterpene acids.
- Authors
Ferreira, Daniele da Silva; Esperandim, Viviane Rodrigues; Toldo, Miriam Paula Alonso; Saraiva, Juliana; Cunha, Wilson Roberto; De Albuquerque, Sérgio
- Abstract
The present study evaluates the in vitro and in vivo trypanocidal activity of ursolic acid and oleanolic acid against the Bolivia strain of Trypanosoma cruzi. Their acute toxicity is also assessed on the basis of median lethal dose (DL50) determination and quantification of biochemical parameters. Ursolic acid is the most active compound in vitro, furnishing IC50 of 25.5 µM and displaying 77% of trypomastigote lysis at a concentration of 128 µM. In agreement with in vitro assays, the results obtained for the in vivo assay reveals that ursolic acid (at a dose of 20 mg/ Kg/day) provides the most significant reduction in the number of parasites at the parasitemic peak. Results concerning the LD50 assay and the biochemical parameters evaluated in the present study demonstrate that these substances can be safely used on an experimental basis.
- Subjects
TRYPANOSOMA; BIOMARKERS; TOXICOLOGY; PARASITES; HERBS
- Publication
Parasitology Research, 2010, Vol 106, Issue 4, p985
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-010-1740-2