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- Title
Sodium glucose cotransporter 2 in mesangial cells and retinal pericytes and its implications for diabetic nephropathy and retinopathy.
- Authors
Masarori Wakisaka; Tetsuhiko Nagao
- Abstract
Retinopathy and nephropathy are life-threatening diabetic complications that decrease patient quality of life. Although the mechanisms underlying these conditions have been extensively studied, they remain unknown. Recent reports have demonstrated the presence of sodium glucose cotransporter 2 (SGLT2) in retinal pericytes and mesangial cells. Hyperglycemia results in functional and morphological changes in these cells, but these effects are attenuated by phlorizin, a nonselective SGLT inhibitor. Based on these findings, we hypothesized that SGLT2 plays a pivotal role in the development of diabetic nephropathy and retinopathy and that SGLT2 inhibitors may directly protect against these complications.
- Subjects
DIABETIC nephropathies; KIDNEY diseases; DIABETES complications; QUALITY of life; SODIUM-glucose cotransporters; HYPERGLYCEMIA; PHLORIZIN
- Publication
Glycobiology, 2017, Vol 27, Issue 8, p691
- ISSN
0959-6658
- Publication type
Article
- DOI
10.1093/glycob/cwx047