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- Title
The role of protein oxidation in the development of diabetic microvascular complications.
- Authors
Mertoglu, Cuma; Siranli, Gulsah; Coban, T. Abdulkadir; Karakurt, Yucel; Ersoy, Alevtina; Ozcicek, Adalet; Arslan, Yusuf; Gok, Gamze; Erel, Ozcan
- Abstract
OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.
- Subjects
OXIDATION; DIABETIC retinopathy; ALBUMINS; DISULFIDES; HOMEOSTASIS
- Publication
Northern Clinics of Istanbul, 2021, Vol 8, Issue 5, p500
- ISSN
2148-4902
- Publication type
Article
- DOI
10.14744/nci.2021.33341