We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neurological Complications in COVID-19 Patients: Can Analysis of Specific Antibodies and Viral RNA in Paired Cerebrospinal Fluid and Serum be Used for Accurate Diagnosis of SARS-CoV-2 Neuroinflammatory Disease? A Case Series.
- Authors
Lauridsen, Karin Holst; Olsen, Kristine Boisen; Lund, Eva Løbner; Jensen, Tomas O.; Pedersen, Thomas Ingemann; Harboe, Zitta Barrella; Antsupova, Valeria; Rasmussen, Lasse Dam; Röser, Dennis; Banner, Jytte; Franck, Kristina Træholt; Jensen, Veronika Vorobieva Solholm
- Abstract
BACKGROUND: Neurological complications during and after SARS-CoV-2 infection have been frequently described. The detection of either SARS-CoV-2 RNA or specific antibodies against SARS-CoV-2 in cerebrospinal fluid in the context of concomitant neurological manifestations indicates neuroinfection. Methods and RESULTS: This is a retrospective descriptive analysis of cerebrospinal fluids and serum samples from 2 hospitalized patients and autopsy findings from 2 patients who died at home. Samples were analysed by 3 independent enzyme-linked immunosorbent assays. Specific antibodies against SARS-CoV-2 were detected in cerebrospinal fluids and paired serum in all 4 cases. Levels of antibodies in cerebrospinal fluids were highest in samples from a deceased man with critical progression of COVID-19 and detectable SARS-CoV-2 viral RNA in cerebrospinal fluid, serum, 4 brain biopsies and 15 additional tissue samples, though immunohistochemical staining for SARSCoV-2 in brain tissue did not detect the virus. CONCLUSION: Detection of SARS-CoV-2 antibodies in paired serum and cerebrospinal fluid may support the presence of SARS-CoV-2 neuroinflammatory disease in patients with COVID-19 and neurological manifestations.
- Subjects
RNA analysis; DISEASE progression; MAGNETIC resonance angiography; COVID-19; BIOPSY; ELECTROENCEPHALOGRAPHY; SERUM; RESEARCH methodology; AUTOPSY; DIZZINESS; RETROSPECTIVE studies; MAGNETIC resonance imaging; RNA; NEUROINFLAMMATION; NEUROLOGIC manifestations of general diseases; SLEEP disorders; SEVERITY of illness index; ENZYME-linked immunosorbent assay; GLASGOW Coma Scale; CASE studies; TISSUES; RESEARCH funding; VIRAL antibodies; CEREBROSPINAL fluid; COVID-19 testing; FATIGUE (Physiology); COMPUTED tomography
- Publication
Clinical Pathology, 2022, Vol 15, p1
- ISSN
2632-010X
- Publication type
Article
- DOI
10.1177/2632010X221139096