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- Title
Rapid determination of amantadine and rimantadine residues in egg by EMR-Lipid solid phase extraction combined with liquid chromato-graphy-tandem mass spectrometry.
- Authors
JIANG Yingjie; GE Zixin; ZHAI Weiwei; SU Jing
- Abstract
A rapid method by EMR-Lipid solid phase extraction combined with liquid chromatography--tandem mass spectrometry was established for determining amantadine and rimantadine residues in eggs. The sample was extracted with acetonitrile with 2% formic acid, purified by EMR-Lipid solid phase extraction column, separated by T3 chromatographic column (100mmx2.1mm, 1.8µm) with acetonitrile -water 0.1% formic acid as mobile phase. The analysis were performed by electrospray positive ion scanning mode under multiple reaction monitoring with matrix matched standard method for quantification. The method had good linear relationship (R > 0.998) in the range of 1.0 ~ 20.0µg/kg for amantadine and rimantadine residues in eggs, the limits of detection were 0.5 µg/kg, the lower limits of quantification were 1.0 µg/kg, the average recoveries were 76.5% ~ 106.8%, and the relative standard deviations were 2.41% ~ 6.81%. This method is simple and fast. In addition, since it does not use isotopic internal standard, cost is reduced. This method is suitable for a rapid determination of large samples.
- Subjects
SOLID phase extraction; MASS spectrometry; AMANTADINE; TANDEM mass spectrometry; LIQUID chromatography-mass spectrometry; FORMIC acid
- Publication
China Food Additives, 2022, Vol 33, Issue 11, p218
- ISSN
1006-2513
- Publication type
Article
- DOI
10.19804/j.issn1006-2513.2022.11.030