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- Title
Tiny Drosophila intestinal stem cells, big power.
- Authors
Zhai, Jingbo; Li, Wanyang; Liu, Xin; Wang, Di; Zhang, Dongli; Liu, Yanli; Liang, Xiuwen; Chen, Zeliang
- Abstract
The signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that can not be addressed using mammalian models. In this review, we discuss recent advances in how we use fly midgut to answer the following key questions: (1) How intestine stem cell niches are established; (2) which factors control asymmetric division of stem cells; (3) how intestinal cells interact with environmental factors, such as tissue damage, microbiota, and diet; (4) how to screen aging/cancer‐related factors or drugs by fly intestine stem cells.
- Subjects
STEM cells; STEM cell niches; DROSOPHILA; INTESTINES; DROSOPHILIDAE
- Publication
Cell Biology International, 2023, Vol 47, Issue 1, p3
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.11911