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- Title
Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells.
- Authors
Florido, Javier; Rodriguez-Santana, César; Martinez-Ruiz, Laura; López-Rodríguez, Alba; Acuña-Castroviejo, Darío; Rusanova, Iryna; Escames, Germaine
- Abstract
This hypothesis was corroborated using 3-TYP, a selective SIRT3 inhibitor that abolishes melatonin's ability to stimulate PDH activity and ROS production, suggesting that the melatonin regulation of SIRT3 is required to reverse the Warburg effect. However, although the majority of studies described the pro-oxidant effects of melatonin on cancer cells, as detailed above, melatonin can also reduce ROS production in some cancer types. Decreased Antioxidant Defenses The pro-oxidant and oncostatic effects of melatonin can be explained by the increased levels of intracellular ROS and by the decrease in antioxidant capacity exhibited in the melatonin-treated cells, as described above. Debate around the Antioxidant Effects of Melatonin in Cancer Cells The beneficial effects of melatonin's antioxidant activity are widely documented in the literature.
- Subjects
CELL death; ACETYLCOENZYME A; SIRTUINS; MELATONIN; DRUG resistance in cancer cells; PYRUVATE dehydrogenase kinase
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081621