We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and evaluation of acetylcholineesterase inhibitory potential and antioxidant activity of benzothiazine derivatives.
- Authors
SHAHWAR, Durre; SANA, Uzma; AHMAD, Naeem
- Abstract
The aim of the present study was to synthesize and characterize benzothiazine derivatives prepared by using 2-aminothiophenol and saccharine and in vitro screen their enzyme inhibition and antioxidant potential. Nine different derivatives were prepared and their structures were confirmed by spectral studies (EIMS, ¹H and 13C NMR). Enzyme inhibition potential of the synthesized compounds was evaluated by Ellman's method, while antioxidant activity was determined by DPPH and FRAP assays. All the derivatives showed remarkable activity against acetylcholine esterase with IC50 values in the range of 35.9-122.0 µM. All other derivatives, except compound 4a, were inactive towards DPPH radical. The results of the FRAP assay showed significant reducing potential of compounds 1, 2, 2a, and 4a.
- Subjects
ESTERASES; ANTIOXIDANTS; BENZOTHIAZINE; CHEMICAL derivatives; PHENOLS; ENZYME inhibitors; CHEMICAL synthesis
- Publication
Turkish Journal of Chemistry, 2013, Vol 37, Issue 2, p262
- ISSN
1300-0527
- Publication type
Article
- DOI
10.3906/kim-1207-67