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- Title
Periokuläre Talgdrüsenkarzinome: Wann auf Muir-Torre-Syndrom testen?
- Authors
Bertelmann, Eckart
- Abstract
Over a period of 1 year, a 74-year-old man slowly developed a painless left upper eyelid intratarsal mass. The skin was movable over the lesion. At surgery, a well-circumscribed, yellow-white, partially cystic tumor was encountered. Histopathologically it was composed of a random mixture of basaloid and sebaceous cells arranged in interconnecting cords. Immunohistochemical evaluation disclosed epithelial membrane antigen, adipophilin, and cytokeratin 14 positivity. These findings led to the diagnosis of a sebaceoma. The tumor cells abnormally failed to express mismatch repair proteins for MLH1 and PMS2. The patient did not have a personal history of any visceral malignancy, but his father had died at the age of 46 years and a daughter at the age of 33 years from colonic carcinomas. The implications of this periocular sebaceoma for the Muir-Torre syndrome are explored.
- Publication
Kompass Ophthalmologie, 2020, Vol 6, Issue 3, p134
- ISSN
2297-0118
- Publication type
Article
- DOI
10.1159/000510224