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- Title
Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease.
- Authors
Adeeb, Salma; Arabi, Tarek Ziad; Shah, Hassan; Alsalameh, Sulaiman; Abu-Shaar, Mylia; El-Sibai, Abduljalil Mohamed; Alkattan, Khaled; Yaqinuddin, Ahmed
- Abstract
Neutrophil extracellular traps (NETs) play an essential role in antimicrobial defense. However, NETs have also been shown to promote and mediate a wide spectrum of diseases, including cancer, diabetes mellitus, cardiovascular diseases, and ocular diseases. Data regarding NETs in ocular diseases remain limited. In physiological conditions, NETs protect the eye from debris and cleave proinflammatory cytokines, including several interleukins. On the other hand, NETs play a role in corneal diseases, such as dry eye disease and ocular graft-versus-host disease, where they promote acinar atrophy and delayed wound healing. Additionally, NET levels positively correlate with increased severity of uveitis. NETs have also been described in the context of diabetic retinopathy. Although increased NET biomarkers are associated with an increased risk of the disease, NETs also assist in the elimination of pathological blood vessels and the regeneration of normal vessels. Targeting NET pathways for the treatment of ocular diseases has shown promising outcomes; however, more studies are still needed in this regard. In this article, we summarize the literature on the protective roles of NETs in the eye. Then, we describe their pathogenetic effects in ocular diseases, including those of the cornea, uvea, and retinal blood vessels. Finally, we describe the therapeutic implications of targeting NETs in such conditions.
- Subjects
RETINAL blood vessels; NEUTROPHILS; DRY eye syndromes; GRAFT versus host disease; THERAPEUTICS; CORNEAL dystrophies; EYE diseases
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 2, p512
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13020512