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- Title
睡眠障碍通过下丘脑- 垂体- 卵巢轴影响女性生育能力的 临床研究.
- Authors
朱争艳; 郭静秋; 陈雪梅; 刘和宇; 宋玉; 雷磊
- Abstract
Objective: Explore how sleep disorders affect female fertility through the hypothalamic-pituitary-ovarian axis. Methods: Eighty women of childbearing age who were admitted to the department of Gynecology and endocrinology of our hospital from October 2018 to October 2021 were selected as the research subjects. According to the evaluation results of Pittsburgh Sleep Quality Index (PSQI), all subjects were divided into a sleep disorder group (n=34) and a non-sleep disorder group (n=46) according to the presence or absence of sleep disorder. PSQI score, serum sex hormone level, menstrual cycle and fertility were compared between the two groups, and the correlation between sleep disorder and female fertility was analyzed by Pearson method. Results: (1) PSQI total score, sleep quality, sleep time, sleep time, sleep efficiency, sleep disorder and daytime dysfunction scores in sleep disorder group were higher than those in control group (P<0.05). (2) The levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the sleep disorder group were higher than those in the non-sleep disorder group, while the level of estradiol (E2) was lower than that in the non-sleep disorder group(P<0.05). (3) The proportion of menstrual disorder in sleep disorder group was higher than that in control group(P<0.05). (4) Comparing the fertility of the two groups, the fertility of the sleep disorder group was lower than that of the control group(P<0.05). (5) Sleep disorder was negatively correlated with FSH and LH, and positively correlated with E2 (P<0.05). Conclusion: Sleep disorders may reduce the drive of the hypothalamic-pituitary-ovarian axis, resulting in slow FSH release, prolonged menstrual cycle, decreased luteal function, and increased transmission rates of non-conception or second ectopic pregnancy.
- Subjects
SLEEP disorders; MENSTRUAL cycle; ECTOPIC pregnancy; CHILDBEARING age; SLEEP quality
- Publication
Progress in Modern Biomedicine, 2022, Vol 22, Issue 9, p1667
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2022.09.013