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- Title
Effect of Intra-articular Parecoxib Sodium Injection on Postoperative Analgesia for Arthroscopic Knee Surgery.
- Authors
DENG Mei; YANG Yun-li; CHEN Bi; LI Jian-gang
- Abstract
Objective The purpose of this study was to investigate the effect of intra-articular parecoxib sodium injection on postoperative analgesia for arthroscopic knee surgery. Methods Sixty patients (ASA I - II , ages 18-65 years) underwent arthroscopic anterior cruciate ligament reconstruction with general anesthesia were randomly divided into two groups (n = 30 each) . Group P (GP) received intra-articular injection of parecoxib sodium 40 mg with normal saline 20 mL, and Group S (GS) received intra-articular injection of normal saline 20 mL. Postoperative analgesia was maintained by intravenous the composition of PCA solution: 1 mg fentanyl plus 10 mg azasetron in 100 mL of normal saline. The PCA setting was as follows: background infusion 2 mL/h, bolus dose 0.5 mL, lockout interval 15 min. The visual analogue scale ( VAS) values were evaluated at rest and at active-passive motion of 2 h , 4 h , 8 h, 12 h, 24 h and 36 h postoperatively. Total analgesic consumption and adverse effects were recorded. Results There were statistically significant differences especially in VAS values with movement at 2 h, 4 h, 8 h and 12 h (P < 0.01) between the two groups. The analgesics consumption and adverse effects of GP patients at the end of 36 h postoperatively were lower than those of GS patients (P < 0.05) . Conclusion Intre-articular parecoxib sodium injection enhanced postoperative analgesia for arthroscopic knee surgery and decreased the analgesics consumption.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p50
- ISSN
2095-610X
- Publication type
Article