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- Title
Diagnosis Effects of 64-Slice CT Joint Serology on Non-small Cell Lung Cancer with Mediastinal Lymph Node Metastasis.
- Authors
DANG Yong; SHANG Shu-ping
- Abstract
Objective The purpose of this study was to evaluate diagnosis effects of 64-slice CT joint serology on non-small cell lung cancer with mediastinal lymph node metastasis. Methods Seventy-two patients with non-small cell lung cancer (Group A) and 40 healthy cases as the control group (Group B) were enrolled. MMP-9, TIMP-1, CEA and CYFRA21-1 levels were detected and the effectiveness of CT and serological testing were analyzed. Results BF and PS values in stage N1 were significantly larger than those in N0 stage (P< 0.05) , and BF, BV and PS of N2 were significantly higher than those of N0 and N1 stages (P< 0.05) . Compared with Group B, there were significant changes of CEA, CYFRA21-1, MMP-9 and TIMP-1 in N0, N1 and N2 patients of Group A (P<0.05) . In Group A, the changes of CEA, CYFRA21-1, MMP-9 and TIMP-1 in N1 patients were more significant than those in N0 patients (P< 0.05) , and those in N2 patients were more significant than those in N0 and N1 stages ( P < 0.05) . Compared with Group B, there were significant changes of CEA, CYFRA21-1, MMP-9 and TIMP-1 in patients with lymph node metastasis of Group A (P < 0.05) . There were significant differences in CEA, CYFRA21-1 and MMP-9 among patients with lymph node metastasis of 1-2, 3-6 and ⩾7 (P< 0.05) , and there was significant difference in TIMP-1 between patients with lymph node metastasis of 3-6 and ⩾ 7 (P< 0.05). Using CEA + CYFRA21-1 + MMP-9 + TIMP-1, the diagnostic accuracy was 69.42% in 72 patients, and the accuracy of a single diagnosis using CT was 89.26%. However, the diagnostic accuracy was 93.07% in patients with mediastinal lymph node metastasis by using CEA + CYFRA21-1 + MMP-9 + TIMP- 1 and CT combination. Conclusion CT and serology for detection of lymph node metastasis of lung cancer can help improve diagnostic performance.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p125
- ISSN
2095-610X
- Publication type
Article