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- Title
Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum.
- Authors
Schueler, Jessica; Alexander, Brenda; Hart, Ann Marie; Austin, Kathleen; Enette Larson‐Meyer, D.
- Abstract
Objective: The presence of appetite hormones, namely glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and leptin in breast milk may be important in infant feeding regulation and infant growth. This study evaluated whether concentrations of GLP-1, PYY, and leptin change across a single feeding (from fore- to hindmilk), and are associated with maternal and infant anthropometrics. Design and Methods: Thirteen postpartum women (mean ± SD: 25.6 ± 4.5 years, 72.0 ± 11.9 kg) provided fore- and hindmilk samples 4-5 weeks after delivery and underwent measurements of body weight and composition by Dual X-ray Absorptiometry. GLP-1, PYY, and leptin concentrations were measured using radioimmunoassay, and milk fat content was determined by creamatocrit. Results: Concentration of GLP-1 and content of milk fat was higher in hindmilk than foremilk ( P ≤ 0.05). PYY and leptin concentrations did not change between fore- and hindmilk. Both leptin concentration and milk fat content were correlated with indices of maternal adiposity, including body mass index ( r = 0.65-0.85, P < 0.02), and fat mass ( r = 0.65-0.84, P < 0.02). Hindmilk GLP-1 was correlated with infant weight gain from birth to 6 months ( r = −0.67, P = 0.034). Conclusion: The presence of appetite hormones in breast milk may be important in infant appetite and growth regulation.
- Subjects
LEPTIN; BREAST milk; GLUCAGON-like peptide 1; INFANT nutrition; REGULATION of body weight; MILKFAT; SURROGATE mothers; DISEASES
- Publication
Obesity (19307381), 2013, Vol 21, Issue 7, p1451
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.20345