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- Title
Control of Skeletal Muscle Myogenesis by Epigenetic Regulations.
- Authors
ZHAO Jun-xing; YUE Wan-fu
- Abstract
Skeletal muscles compose about 50% of the body's masses and consider as the largest organ in the body. Skeletal muscle myogenesis is a highly controlled process. During myogenesis, quiescent muscle stem cells are activated and proliferated response to environmental stress, and then differentiated muscle fiber. The specification, proliferation and termination of skeletal muscle cell are coordinated by expression of different transcriptional factors, including Pax3/Pax7, MyoD, Myf5, Myogenin and MRF4, etc.. Epigenetics can be defined as heritable changes in gene function that occur without primary DNA sequence modification. More and more studies indicated that epigenetic modifications of transcriptional factors control a set of genes expression, which further define myogenesis. This review summarized the mechanism of the " epigenetic network ", including histone tails modification, DNA methylation and miRNA in regulating myogenesis.
- Subjects
MYOGENESIS; MUSCLES; TRANSCRIPTION factors; METHYLATION
- Publication
Journal of Agricultural Science & Technology (1008-0864), 2014, Vol 16, Issue 3, p42
- ISSN
1008-0864
- Publication type
Article
- DOI
10.13304/j.nykjdb.2013.441