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- Title
The framework for population epigenetic study.
- Authors
Zhao, Linna; Liu, Di; Xu, Jing; Wang, Zhaoyang; Chen, Yang; Lei, Changgui; Li, Ying; Liu, Guiyou; Jiang, Yongshuai
- Abstract
At present, understanding of DNA methylation at the population level is still limited. Here, we first extended the classical framework of population genetics, such as single nucleotide polymorphism allele frequency, linkage disequilibrium(LD), LD block and haplotype, to epigenetics. Then, as an example, we compared the DNA methylation disequilibrium (MD)maps between HapMap CEU (Caucasian residents of European ancestry from Utah) population and YRI (Yoruba people from Ibadan) population (lymphoblastoid cell lines). We analyzed the differences and similarities between CEU and YRI from the following aspects: SMP (single methylation polymorphism) allele frequency, SMP allele association, MD, MD block andmethylation haplotype (meplotype) frequency. The results showed that CEU and YRI had similar distribution of SMP allele frequency, and sharedmany MD block region. We believe that the framework of population genetics can be used in the population epigenetics. The population epigenetic framework also has potential prospects in the study of complex diseases, such as epigenome-wide association study.
- Subjects
EPIGENETICS; DNA methylation; POPULATION genetics; LINKAGE disequilibrium; HAPLOTYPES
- Publication
Briefings in Bioinformatics, 2018, Vol 19, Issue 1, p89
- ISSN
1467-5463
- Publication type
Article
- DOI
10.1093/bib/bbw098