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- Title
Striatal adenosine A<sub>2A</sub> receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus.
- Authors
Xiang-Shan Yuan; Lu Wang; Hui Dong; Wei-Min Qu; Su-Rong Yang; Cherasse, Yoan; Lazarus, Michael; Schiffmann, Serge N.; de Kerchove d'Exaerde, Alban; Rui-Xi Li; Zhi-Li Huang
- Abstract
Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A2A receptors (A2ARs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A2AR neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A2AR neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A2AR neurons. In addition, chemogenetic inhibition of striatal A2AR neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A2AR neuron/GPe PV neuron circuit in sleep control.
- Subjects
ADENOSINES; NEURONS; PARVALBUMINS; GLOBUS pallidus; SLEEP-wake cycle; SLEEP disorders
- Publication
eLife, 2017, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.29055