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- Title
DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection.
- Authors
Sugiyama, Tomohiro; Iwaizumi, Moriya; Kaneko, Masanao; Tani, Shinya; Yamade, Mihoko; Hamaya, Yasushi; Furuta, Takahisa; Miyajima, Hiroaki; Osawa, Satoshi; Baba, Satoshi; Maekawa, Masato; Sugimoto, Ken
- Abstract
The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently increasing use of endoscopic techniques to cure a number of these patients. In the present study, the DNA MMR status for stage 0 patients with CRC treated using endoscopic submucosal dissection or endoscopic mucosal resection was analyzed via immunohistochemical staining of four types of proteins, namely MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2 MMR system component, in adenocarcinoma specimens. Notably, none of the endoscopically resected specimens exhibited dMMR among the 41 patients diagnosed with stage 0 CRC. Since tumors harboring dMMR progress more rapidly than tumors with chromosomal instability, the present results highlight the importance of tumor resection during very early phases that exist before the promoter region of MLH1 becomes hypermethylated, resulting in a loss of DNA MMR function.
- Subjects
DNA mismatch repair; COLORECTAL cancer; HEREDITARY nonpolyposis colorectal cancer; ENDOSCOPIC surgery; IMMUNOSTAINING
- Publication
Oncology Letters, 2020, Vol 20, Issue 3, p2435
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.11799