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- Title
ON cone bipolar cells in rat express the metabotropic receptor mGluR6.
- Authors
Vardi, Noga; Morigiwa, Katsuko
- Abstract
The rod bipolar cell and about five types of ON cone bipolar cells depolarize to light by employing a sign-reversing metabotropic glutamate receptor. Glutamate responses are similar in both rod bipolar and cone bipolar cells, but the receptor mediating this response (mGluRo) was so far demonstrated only in rod bipolar cells. To test if ON cone bipolar cells also express mGluR6, we immunoreacted rat retina with an antibody specific for mGluRo, and studied the staining from serial ultrathin sections. We demonstrate that mGluR6 is indeed expressed in the dendritic tips of cone bipolar cells, the majority of which receive a ribbon synapse, and thus probably are ON cone bipolar cells. We further show that half of the dendritic tips contacting the cones stain for mGluR6, thus implying that all ON cone bipolar cell types express mGluR6.
- Publication
Visual Neuroscience, 1997, Vol 14, Issue 4, p789
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523800012736