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- Title
Alternative splicing regulation in tumor necrosis factor-mediated inflammation (Review).
- Authors
LÓPEZ-URRUTIA, EDUARDO; CAMPOS-PARRA, ALMA; HERRERA, LUIS ALONSO; PÉREZ-PLASENCIA, CARLOS
- Abstract
It is generally accepted that alternative splicing has an effect on disease when it leads to conspicuous changes in relevant proteins, but that the combinatorial effect of several small modifications can have marked outcomes as well. Inflammation is a complex process involving numerous signaling pathways, among which the tumor necrosis factor (TNF) pathway is one of the most studied. Signaling pathways are commonly represented as intricate cascades of molecular interactions that eventually lead to the activation of one or several genes. Alternative splicing is a common means of controlling protein expression in time and space; therefore, it can modulate the outcome of signaling pathways through small changes in their elements. Notably, the overall process is tightly regulated, which is easily overlooked when analyzing the pathway as a whole. The present review summarizes recent studies of the alternative splicing of key players of the TNF pathway leading to inflammation, and hypothesizes on the cumulative results of those modifications and the impact on cancer development.
- Subjects
ALTERNATIVE RNA splicing; TUMOR necrosis factor regulation; INFLAMMATION; CELLULAR signal transduction; MOLECULAR interactions
- Publication
Oncology Letters, 2017, Vol 14, Issue 5, p5114
- ISSN
1792-1074
- Publication type
Article