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- Title
Expression and clinical significance of glucose transporter-1 in pancreatic cancer.
- Authors
XINGYU LIN; ZHIGUANG YANG; PENG ZHANG; YUNPENG LIU; GUOGUANG SHAO
- Abstract
Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The glucose transporter-1 (GLUT-1) is overexpressed in a variety of malignant tumors. However, the association between GLUT-1 expression and clinicopathological factors, 18F-fluorodeoxyglucose uptake and tumor proliferation in pancreatic cancer has not been investigated to date. In the present study, the expression of GLUT-1 in 53 pancreatic cancer tissues was analyzed, which revealed that GLUT-1 was overexpressed in pancreatic tissue and correlated with poor prognosis and clinicopathological characteristics, including increased tumor size, clinical stage and lymph node metastasis, maximum standardized uptake value (SUVmax) and Ki-67 expression. The receiver operating characteristic curve analysis indicated that a cut-off SUVmax value of 4.830 was associated with optimal sensitivity (88%) and specificity (71.4%) for the detection of strong positive GLUT-1 expression. In addition, as the expression of GLUT-1 was found to correlate with Ki-67 expression, GLUT-1 may exhibit a significant effect on cell proliferation in pancreatic cancer. Overall, these findings indicate that GLUT-1 may represent a prognostic indicator, and a potential therapeutic target for pancreatic cancer.
- Subjects
GLUCOSE transporters; PANCREATIC cancer; SURVIVAL behavior (Humans); CELL proliferation; GENE expression
- Publication
Oncology Letters, 2016, Vol 12, Issue 1, p243
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4586