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- Title
Nesfatin-1 levels in patients with slow coronary flow.
- Authors
Kuyumcu, Mevlüt Serdar; Kuyumcu, Aliye; Yayla, Çağrı; Özbay, Mustafa Bilal; Alagöz, Mehmet; Ünal, Sefa; Açar, Burak; Özeke, Özcan; Samur, Gülhan
- Abstract
Background: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. Aim: We aimed to evaluate the relationship between nesfatin-1 levels and slow coronary flow (SCF). Methods: A total of 60 consecutive patients with SCF and 60 consecutive patients with normal coronary flow (NCF) were enrolled into the study. Nesfatin-1 level was measured from blood serum samples using enzyme-linked immunosorbent assay test. Results: Serum nesfatin-1 levels were significantly lower in the SCF group compared to the NCF group (p < 0.001). Low levels of nesfatin-1 were found to be significantly and independently associated with the SCF (odds ratio 0.982, 95% confidence interval 0.969--0.995, p = 0.005). Conclusions: The results of this study showed that serum nesfatin-1 level was lower in the SCF group than in the NCF group. Nesfatin-1 could play a role in the pathogenesis of SCF phenomenon with mechanisms such as inflammation and endothelial dysfunction. Further studies are needed to determine the relation between SCF and nesfatin-1.
- Subjects
CONFIDENCE intervals; CORONARY arteries; CORONARY circulation; ENDOTHELIUM; ENZYME-linked immunosorbent assay; INFLAMMATION; NEUROPEPTIDES; ODDS ratio
- Publication
Polish Heart Journal / Kardiologia Polska, 2018, Vol 76, Issue 2, p401
- ISSN
0022-9032
- Publication type
Article
- DOI
10.5603/KP.a2017.0210