We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mutational analysis of severe acute respiratory syndrome coronavirus 2 in immunocompromised patients with persistent viral detection using whole genome sequencing.
- Authors
Chang, Euijin; Lee, Jungmin; Kim, Jun‐Won; Seok, Jong Hyeon; Bae, Joon‐Yong; Kim, Jeonghun; Park, Heedo; Jang, Choi‐Young; Kang, Sung‐Woon; Lim, So Yun; Kim, Ji Yeun; Yang, Jeong‐Sun; Kim, Kyung‐Chang; Lee, Joo‐Yeon; Park, Man‐Seong; Kim, Sung‐Han
- Abstract
This article explores the use of whole genome sequencing (WGS) to analyze the mutations of the SARS-CoV-2 virus in immunocompromised patients with persistent viral detection. The study, conducted at a tertiary teaching hospital, included 13 patients and found that each patient had unique and different mutations distributed throughout the entire SARS-CoV-2 genome. These findings suggest that immunocompromised patients may contribute to the emergence of new variants. The study focused on mutations during the Omicron era and found that patients acquired a median of two amino acid substitutions over a median of 51 days, with most mutations occurring in specific regions of the genome. Some mutations were associated with immune evasion, remdesivir resistance, and the emergence of new variants. The study suggests that immunocompromised individuals with persistent viral detection should be cautious about ending isolation, but the results may not apply to all immunocompromised populations due to limitations in the study.
- Subjects
SARS-CoV-2; WHOLE genome sequencing; IMMUNOCOMPROMISED patients; VIRAL shedding
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 11, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1462