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- Title
Serum amlyoid A: An inflammatory adipokine mediating postburn outcomes.
- Authors
Abdullahi, Abdikarim; Stanojcic, Mile; Yu, Nancy; Samadi, Osai; Sadri, Ali‐reza; Vinaik, Roohi; Coburn, Natalie; Jeschke, Marc G.
- Abstract
Furthermore, when we profiled SAA levels in burn patients who succumbed to the injury, SAA levels were significantly higher in the nonsurvivors relative to burn patients who survived the injury (Figure 1C). (B) Circulating SAA levels were measured in plasma from nonburn controls, burn patients, and septic burn patients at early (0-3 days) and late (>14 days) time points postinjury. We report here that the acute phase protein serum amyloid A (SAA) mediates chronic inflammation and poor outcomes in both burn and septic burn patients. Dear Editor, Burn trauma is associated with increased mortality rates despite many key advances and therapeutic strategies to improve patient care.1 One of the main drivers of poor outcomes in these patients is the complex yet overwhelming chronic inflammation that occurs in response to the injury.2 Unfortunately, the mechanisms, and in particular the signaling circuitry that facilitates persistent inflammation in these patients are essentially unknown.
- Subjects
ADIPOSE tissue physiology; NEONATAL sepsis; VASCULAR endothelial growth factor receptors
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 6, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.412