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- Title
EVALUATION OF SERUM URIC ACID LEVELS IN PATIENTS WITH PRIMARY THYROID DYSFUNCTION.
- Authors
Ayyub, Aisha; Muhammad Asif Nawaz; Khan, Muhammad Basharat
- Abstract
OBJECTIVE: To evaluate the levels of serum uric acid in the patients with primary thyroid dysfunction METHODS: This cross-sectional study was carried out at Military Hospital (MH) Rawalpindi, Pakistan from July-December 2014 after obtaining the ethical and institutional permission. A total of sixty patients of both genders and newly diagnosed with primary thyroid dysfunction were recruited. Informed written consent was obtained from each participant. Patients were categorized in 4 primary hyperthyroid (serum TSH <0.40 mIU/L and elevated fT ) and primary 4 hypothyroid (serum TSH >4.50 mIU/L and reduced fT ) groups. Serum uric acid levels of both groups were estimated and levels >420 μmol/L in males and >360 μmol/L in females were labeled as hyperuricemia. Results were entered and analyzed through SPSS version 21. RESULTS: Out of sixty participants, 21 (35%) patients were male while 39 (65%) patients were females and mean age was 42.31±11.27 years. Primary hypothyroidism group consisted of 43 (71.7%) patients while 17 (28.3%) patients were in primary hyperthyroidism group. Elevated serum uric acid levels were present in 65% patients (n=39). In the patients with hypothyroidism, 31 out of 43 (72%) patients were diagnosed with hyperuricemia while the corresponding numbers in hyperthyroid group were 8 out of 17 (47%). However, difference among mean Serum uric acid levels of both groups was insignificant (385.27±182 μmol/L and 316.95±169 μmol/L, p>0.01). CONCLUSION: Patients with primary thyroid dysfunction have elevated serum uric acid levels that are more frequent in primary hypothyroidism as compared to primary hyperthyroidism.
- Subjects
HYPERURICEMIA; THYROID diseases; HYPERTHYROIDISM diagnosis; PATIENTS
- Publication
Khyber Medical University Journal, 2018, Vol 10, Issue 2, p86
- ISSN
2305-2643
- Publication type
Article
- DOI
10.35845/kmuj.2018.17964