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- Title
Lymphocyte activation by streptococcal antigens in psoriasis.
- Authors
Gross, W. L.; Packhäuser, U.; Hahn, G.; Westphal, E.; Christophers, E.; Schlaak, M.
- Abstract
Cell-mediated immune responses in 28 hospitalized patients with psoriasis and in 36 healthy controls were studied using the two-step leukocyte migration agarose test. Specific cell-mediated immunity to A-streptococcal cell wall and cell membrane antigens occurred significantly more often in patients with psoriasis than in the control group. A statistically significant correlation between psoriasis- associated antigens of the HLA-B locus and cellular immune reactivity to A-streptococcal antigens or clinical course was not found. When patients with guttate psoriasis were compared separately with the control group, leukocyte migration inhibition induced by cell-free supernatants of A-streptococcal antigen-exposed mono-nuclear cell cultures was found to be more frequent than in other forms of psoriasis.
- Subjects
PSORIASIS; LYMPHOCYTES; ANTIGENS; IMMUNE response; LEUCOCYTES; IMMUNITY
- Publication
British Journal of Dermatology, 1977, Vol 97, Issue 5, p529
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1977.tb14130.x