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- Title
Meta-Analysis of Matrix Metalloproteinases in the Risk of Cardiovascular and Neurodegenerative Diseases.
- Authors
Huang, Ruizhen; XinYang; Zhu, Rui; Song, Junkun; Luo, Mei; Chen, Di-ang
- Abstract
Objective. To investigate the risk of cardiovascular and neurodegenerative diseases induced by matrix metalloproteinases (MMPs) by meta-analysis. Methods. Relevant literature was searched from Wanfang Medical Center, CNQI, VIP, PubMed, and other domestic and foreign literature databases for the research direction, and the risk of cardiovascular and neurodegenerative diseases induced by MMPs was meta-analyzed using the fixed-effect model and random-effect model. Results. MMP-1 and MMP-9 were risk factors for cardiovascular diseases by fixed and random-effect model analysis, respectively, while MMP-2 and MMP-9 were risk factors for increased neurodegenerative diseases by random-effect model analysis. Conclusion. MMP-1 and MMP-9 are risk factors for cardiovascular diseases, and MMP-2 and MMP-9 are major factors for increased risk of neurodegenerative diseases. MMP-1, MMP-2, and MMP-9 can be used as new targets for clinical diagnosis, treatment, and research of subsequent cardiovascular and neurodegenerative diseases.
- Subjects
RISK factors of neurodegeneration; CARDIOVASCULAR diseases risk factors; ONLINE information services; BIOMARKERS; META-analysis; SYSTEMATIC reviews; RISK assessment; MATRIX metalloproteinases; DESCRIPTIVE statistics; MEDLINE
- Publication
BioMed Research International, 2022, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2022/3360316