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- Title
Osteonecrosis of the calvarium: When clear margins are an impractical goal.
- Authors
Liakos, William; Siddiqui, Fariha; Toussi, Atrin; Le, Stephanie; Kian, Sara; Li, Qinyuan; Leal, Annie Riera; Maverakis, Emanual
- Abstract
Cutaneous squamous cell carcinoma (SCC) is the second most common cutaneous malignancy in the United States, with increased frequency in immunosuppressed individuals or those exposed to ultraviolet radiation.1 Overall, 2% to 5% of SCCs spread to lymph nodes or more distant sites.1 Surgical excision remains the "gold standard", though depending on patients' comorbidities, topical, intralesional (IL), or radiation therapy may also be appropriate.1 In this report, we describe a case of SCC of the scalp treated with repeated, extensive measures resulting in a poor outcome. IL 5-FU, intralesional fluorouracil 50 mg/mL gl Over the next 2 months, she underwent weekly intralesional fluorouracil (IL 5-FU) treatments without improvement (Figure 2B). Despite these comorbidities, the patient received aggressive treatments for her SCC including radiation therapy, intralesional chemotherapy, and multiple surgeries ultimately resulting in a necrosed and exposed calvarium.
- Subjects
CALVARIA; OSTEONECROSIS; COMPUTED tomography; ACTINIC keratosis
- Publication
Dermatologic Therapy, 2020, Vol 33, Issue 6, p1
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.14278