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- Title
Use of vismodegib for the treatment of multiple basal cell carcinomas in a patient with xeroderma pigmentosum.
- Authors
Soura, Efthymia; Plaka, Michaela; Dessinioti, Clio; Chasapi, Vassiliki; Stefanaki, Christina; Antoniou, Christina; Stratigos, Alexander
- Abstract
A female patient with xeroderma pigmentosum and multiple basal cell carcinomas was treated with a hedgehog pathway inhibitor (vismodegib), which successfully treated the majority of her basal cell carcinomas while preventing the appearance of new lesions. The sum diameter of lesions showed a 61% decrease after 16.5 months of treatment, although after 18.5 months of treatment, a persistent lesion showed progression and metatypical characteristics; adverse events included persistent alopecia muscle cramps, dysgeusia, and amenorrhea. Despite these limitations, vismodegib may have a role in the treatment of some patients with xeroderma pigmentosum.
- Subjects
BASAL cell carcinoma treatment; XERODERMA pigmentosum; SQUAMOUS cell carcinoma; DRUG side effects; SKIN disease treatment
- Publication
Pediatric Dermatology, 2018, Vol 35, Issue 6, pe334
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.13610